Tag Archives: causes

Future Brain

Is Parkinson’s an autoimmune disease?

Inflammatory processes can initiate a “complement cascade” leading to “waves of synaptic destruction that characterize neurodegenerative disease”. It can be inferred from the Stanford study that Parkinson’s disease can indeed be described as an autoimmune disease, as accumulation of the C1q protein, in combination with an inflammatory trigger, creates an immune response that destroys synapses.

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Copper and Parkinson's

Copper and Parkinson’s disease: Is it a cause as well?

Is the copper link strong in Parkinson’s disease as well? Initial runs of the algorithm are pulling up potential causal associations to redox-active metals like crazy. Very, very preliminary runs. But watch out for more on the associations between copper and Parkinson’s disease. It may be a general feature of many neurodegenerative diseases.

  • Description: “Copper appears to be one of the main environmental factors that trigger the onset and enhance the progression of Alzheimer’s disease by preventing the clearance and accelerating the accumulation of toxic proteins in the brain. That is the conclusion of a study appearing today in the journal Proceed…
  • Source Link: http://www.urmc.rochester.edu/news/story/index.cfm?id=3916

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Steve Ludzik

Early onset Parkinson’s with a history of head trauma and Crohn’s disease

Hockey coach Steve Ludzik takes 22 pills daily to control his Parkinson’s symptoms. He is sure that blows to his head is the cause of his early onset Parkinson’s. But he has also suffered from Crohn’s disease, an inflammatory condition, for all of his adult life.

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Dr. Patrik Brundin

Parkinson’s disease starts with sense of smell then spreads

New research suggests that misfolded proteins in Parkinson’s patients spread from the olfactory bulb (and regions that affect the gut) to other regions of the brain.

“A major unmet medical need is a therapy that slows disease progression,” said Dr. Patrik Brundin, who leads Parkinson’s research at VAI and is senior author of the study. “We hope an understanding of how (the protein) moves between brain regions will help uncover molecules that we can target with new drugs to slow the progression of symptoms in patients.”

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mitophagy

Keeping our mitochondria healthy by boosting mitophagy?

Keep your mitochondria healthy or this genetic mutation will not take out the trash. Now, how do we boost mitophagy? This may be the key to healthy neurons.

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JCI Cover

Glucose control and Parkinson’s disease

Glucose control may be one way to slow the degenerative process in Parkinson’s. Once again we see an association of blood glucose, diabetes and neurodegenerative diseases.

  • Description: “1Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, United Kingdom. 2Department of Nuclear Medicine, University College London Hospitals NHS Trust, London, United Kingdom. 3Reta Lila Weston Laboratories, London, United Kingdom. 4UCL School of Pharmacy, London, United Kingdo…
  • Source Link: http://www.jci.org/articles/view/68295

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Parkinson's Mutation

Parkinson’s Disease As Impaired Autophagy

Clogging the vacuum: How Parkinson’s disease is caused by impaired autophagy.

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Steve Reed

Potential Cause of Parkinson’s Disease that Points to a New Therapeutic Strategy

A genetic mutation that is responsible for a small minority of Parkinson’s cases points to the contribution of chronic neuroinflammation and oxidative stress that probably underlies all “sporadic” cases of Parkinson’s disease.

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Neuronal Iron

Does iron cause Parkinson’s disease?

Does iron cause Parkinson’s disease? As usual, the epidemiology is conflicting, at least the interpretation is difficult. Higher blood iron is associated with a reduction of Parkinson’s rates, while higher consumption (non-heme iron) is associated with higher Parkinson’s rates. Of course it’s possible that higher blood iron is also associated with lower tissue concentrations. Lots more in the future about the contribution of iron to many degenerative diseases, I predict.

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