Tag Archives: facebook link post

Jeff Coxx

Parkinson’s disease may be a failure to see old mitochondria as invading bacteria

Early onset Parkinson’s subtype may be a failure to see old mitochondria as invading bacteria. It turns out that the same PARK2 mutation that causes some early onset Parkinson’s cases, also leads to greater sensitivity to intracellular bacterial infections. Interestingly, mitochondria were once intracellular bacteria, a billion years ago.

posted on my Facebook page: Parkinson’s News

Normal Brain

New drug discovery technique using skin cells reveals promising new drugs

Skin cells with a genetic defect found in a small number of Parkinson’s cases, specifically autosomal recessive juvenile Parkinson’s disease. Essentially, the mutation makes mitochondria, the cell’s energy factories, sick. Out of 2,000 compounds, the screen found a family of new drugs, including an existing drug called UDCA, that allowed the mitochondria to work again. Very nicely done!

posted on our Facebook fan page: Stop Parkinson’s Disease

One Creative Dad

How do you tell your kids you have Parkinson’s?

How to tell your kids you have Parkinson’s? See the creative steps this Dad took to tell his kids, and the world, about “a very tough disease”.

See the animated poem that he created:

posted on my Facebook page: Parkinson’s News

Phosphorylation

How protein phosphorylation in Parkinson’s disease went from culprit to potential cure.

From culprit to cure. How protein phosphorylation in Parkinson’s disease went from “scene of the crime” suspect to neuroprotective mechanism and potential treatment.

In the process, scientists learned an important lesson: “The lesson we learned from this research is that everything you find at the scene of a crime is not necessarily involved in the crime. By remaining fixated on that assumption, we may lose sight of the bigger picture.

posted on my Facebook page: Parkinson’s News

Parkinson's Markers

Parkinson’s disease markers will enable earlier diagnosis

Here’s a worthy effort to identify Parkinson’s disease markers by the Michael J. Fox Foundation. Such markers would allow earlier detection and diagnosis of the disease, and would benefit future treatments designed to slow or even stop the degeneration.

posted on my Facebook page: Parkinson’s News

Drawing by Charcot of a Parkinson's disease patient in Morocco, 1889

Does inflammation cause depression, fatigue, cognitive impairment in Parkinson’s?

Neuroinflammation is associated with severe depression, fatigue, and cognitive impairment in Parkinson’s sufferers. The question seems to be, is it causal? Keep an eye on further news on the topic of inflammation in Parkinson’s disease research.

  • Description: “Grand Rapids, Mich. (Aug. 26, 2013) – A researcher from Michigan State University College of Human Medicine and Van Andel Institute (VAI) has, together with Swedish researchers shown, for the first time, significant associations between high levels of pro-inflammatory markers in cerebrospinal fluid…
  • Source Link: http://www.vai.org/NewsRoom/press-release-8-26-13.aspx

posted on my Facebook page: Parkinson’s News

AIMP2 and PARP1

Will PARP inhibitors protect dopamine-making neurons in humans?

Will PARP inhibitors protect dopamine-making neurons in humans? These same drugs are currently undergoing clinical trials for breast, ovarian and colorectal cancer, and melanoma. There is reason to believe they may be helpful in Parkinson’s disease as well. Unfortunately, any clinical trials are a long way away.

posted on my Facebook page: Parkinson’s News

Monica Hall

Deep brain simulation for late-stage, early onset Parkinson’s

Deep brain simulation for late-stage, early onset Parkinson’s. I’m trying not to cover palliative care too much, but thought this might provide some hope for those for whom medications no longer work well.

posted on my Facebook page: Parkinson’s News