The same PARK2 mutation that causes some early onset Parkinson’s cases, also leads to greater sensitivity to intracellular bacterial infections.
Drugs called PARP inhibitors are currently undergoing clinical trials for a number of cancers. Will they be helpful in Parkinson’s disease as well?
Keep your mitochondria healthy or this genetic mutation will not take out the trash. Now, how do we boost mitophagy? This may be the key to healthy neurons. Description: “Research has linked the disease to a genetic defect that stops cells clearing out defective mitochondria, tiny metabolic generators that supply energy.“ Source Link: http://www.dailymail.co.uk/health/article-2389706/Parkinsons-disease-caused-genetic-defect-claim-scientists-believe-closer-treating-condition.html?ito=feeds-newsxml posted […]
Clogging the vacuum: How Parkinson’s disease is caused by impaired autophagy. Description: “GENETICS 2013: A study published in March in Nature Neuroscience reported that mutations on the LRRK2 gene, responsible for approximately 15% of Parkinson’s among Ashkenazi Jews, leads to the malfunctioning of a disposal system in the cell that recycles old proteins.“ Source Link: […]