Argonaute2

RNA interference is a possible cure for Parkinson’s Disease

Researchers in San Diego are now a step closer to understanding and utilizing a technique that one day could be used to block proteins responsible for diseases like Parkinson’s. The technique is called RNA interference and it is a natural process that researchers hope to hijack.

A number of diseases can basically be described as undesired levels of specific cellular proteins. These diseases are in the minds of the researchers as they study RNA interference because understanding this process has the potential to lead to real cures for those diseases.

  • Description: “(Phys.org) —Researchers hope to hijack a natural process called RNA interference to block the production of proteins linked to disease and treat medical conditions for which conventional drugs do not work, including cancer, heart disease, HIV and Parkinson’s disease.
  • Source Link: http://phys.org/news/2013-09-hijacked-protein-therapeutic-interventions.html

posted on my Facebook page: Parkinson’s News

CoQ10 Powder

Should I take CoQ10 for my Parkinson’s?

Since I’ve started working on this project to slow Parkinson’s, quite a number of people have asked me about a dietary supplement called Coenzyme Q10, commonly abbreviated CoQ10. It is a natural substance in your body that is critical to mitochondria, the power generators in your cells.

CoQ10 has gained interest from the alternative health community because it also functions as a potent antioxidant for both lipids and proteins, and can also regenerate other antioxidants. Also, oral supplementation of CoQ10 is effective at replenishing the body’s concentrations of CoQ10. And since many disease conditions deplete CoQ10, an obvious way to help fight those diseases is to supplement with CoQ10.

Indeed, many studies have generated evidence suggesting that CoQ10 is beneficial for a number of conditions. It also may correct a potentially dangerous side effect of statin use, which reduces serum levels of CoQ10 dramatically. The desire for supplementation has increased steadily over the past 10 years, and prices have dropped.

Regarding Parkinson’s disease, there was the feeling that CoQ10 could be helpful because oxidative stress is involved in Parkinson’s disease, either as a cause or an effect, depending on the Parkinson’s subtype. Parkinson’s also involves the inability to properly dispose of old or damaged mitochondria (mitophagy), so the desire to keep mitochondria healthy was reasonable.

Like other diseases, patients with Parkinson’s disease are also deficient in CoQ10. Additionally, CoQ10 appears to be effective at protecting dopaminergic neurons and other brain tissue from certain toxins and other insults (neuroprotection). I suspect that CoQ10 supplementation may be useful as part of a prevention strategy for those who are at greater risk of developing Parkinson’s. Supplementation also appears to be useful for certain patients that experience headaches and migraines.

However, increasing mitochondrial longevity through CoQ10 supplementation might have value for only certain subtypes of Parkinson’s patients . For those patients, one would at least want to pair CoQ10 with a mitophagy inducer. Our algorithms are busy examining the data, looking for existing supplements and compounds that should be effective as mitophagy inducers.

Indeed, a large clinical trial of CoQ10 in Parkinson’s patients was stopped in 2011 because it failed to show any particular benefit. This was disappointing because a number of animal models showed significant benefit of CoQ10. It is important to note that these were general Parkinson’s patients, not segmented based on subtype. I would be curious if certain subtypes would see more benefit, but I’m skeptical that CoQ10 supplementation alone would slow Parkinson’s neurodegeneration significantly.

The experiment on humans was certainly worth doing, however Parkinson’s is not a single issue that can be slowed with a single supplement. By the time somebody is diagnosed, there is an avalanche of multiple issues, caused by problems in multiple pathways, requiring multiple directions of attack. Multiple supplements are required to attack Parkinson’s from these directions. Adding to this complexity is that Parkinson’s is made up of multiple subtypes, each with a different origin. The mission of this project is to determine exactly what combination of supplements, and in what quantities, would benefit the most patients.

Phrenology Phigures

Regenerating neurons in Parkinson’s disease by activating the Axin pathway

Researchers in Hong Kong have identified a protein, Axin, that plays a key role in the production of neurons. They feel that by manipulating this pathway they can also help people with Autism and will be able to apply this discovery towards regenerating neurons in people with Parkinson’s disease. Unfortunately the researchers feel that any treatment based on this discovery is 10 years away.

posted on my Facebook page: Parkinson’s News

hands

Older vs. early onset Parkinson’s – Is there a difference in goals?

What are your desires for Parkinson’s? Is there an essential difference between older people with Parkinson’s and those with the early onset version of the disease? What are your thoughts?

“We want a cure,” said Kelly Campbell Thomson. “I want to be cured, but (most) older people with Parkinson’s want better medications and comfort, which is fine … but there’s where the line is drawn.

“I don’t want comfort, I want the cure.”

posted on my Facebook page: Parkinson’s News

Jeff Coxx

Parkinson’s disease may be a failure to see old mitochondria as invading bacteria

Early onset Parkinson’s subtype may be a failure to see old mitochondria as invading bacteria. It turns out that the same PARK2 mutation that causes some early onset Parkinson’s cases, also leads to greater sensitivity to intracellular bacterial infections. Interestingly, mitochondria were once intracellular bacteria, a billion years ago.

posted on my Facebook page: Parkinson’s News

Normal Brain

New drug discovery technique using skin cells reveals promising new drugs

Skin cells with a genetic defect found in a small number of Parkinson’s cases, specifically autosomal recessive juvenile Parkinson’s disease. Essentially, the mutation makes mitochondria, the cell’s energy factories, sick. Out of 2,000 compounds, the screen found a family of new drugs, including an existing drug called UDCA, that allowed the mitochondria to work again. Very nicely done!

posted on our Facebook fan page: Stop Parkinson’s Disease

Filter and Fan

Progress on The Machine: added mesh filtration and exhaust fan.

We’ve made some progress in the construction and testing of the machine. Concerns about heat and dust infiltration were solved (we hope) by inserting high open area, low open size woven mesh sheeting over the top and side grills. This will act as a filter that can be cleaned using compressed air. Also, we placed an exhaust fan over the hottest spot on the grill in order to keep interior temperatures reasonable.
uploaded on our Facebook fan page: Stop Parkinson’s Disease
One Creative Dad

How do you tell your kids you have Parkinson’s?

How to tell your kids you have Parkinson’s? See the creative steps this Dad took to tell his kids, and the world, about “a very tough disease”.

See the animated poem that he created:

posted on my Facebook page: Parkinson’s News

Phosphorylation

How protein phosphorylation in Parkinson’s disease went from culprit to potential cure.

From culprit to cure. How protein phosphorylation in Parkinson’s disease went from “scene of the crime” suspect to neuroprotective mechanism and potential treatment.

In the process, scientists learned an important lesson: “The lesson we learned from this research is that everything you find at the scene of a crime is not necessarily involved in the crime. By remaining fixated on that assumption, we may lose sight of the bigger picture.

posted on my Facebook page: Parkinson’s News